Methyl ([(benzyloxy)carbonyl]amino)acetate
methyl N-benzyloxycarbonylglycinate
CAS: 1212-53-9
Molecular Formula: C11H13NO4
Methyl ([(benzyloxy)carbonyl]amino)acetate - Names and Identifiers
| Name | methyl N-benzyloxycarbonylglycinate |
| Synonyms | Z-Gly-OMe Z-Gly-Ome Z-GLY-OME methyl glycinate TIMTEC-BB SBB007667 Z-GLYCINE METHYL ESTER CBZ-Glycine methyl ester N-CBZ-GLYCINE METHYL ESTER N-CBZ-Glycine Methyl Ester Carbobenzoxyglycine methyl ester Carbobenzyloxyglycine Methyl Ester methyl N-benzyloxycarbonylglycinate N-ALPHA-CARBOBENZOXY-GLYCINE METHYL ESTER Methyl ([(benzyloxy)carbonyl]amino)acetate Glycine, N-[(phenylmethoxy)carbonyl]-, methyl ester |
| CAS | 1212-53-9 |
| EINECS | 214-922-8 |
| InChI | InChI=1/C11H13NO4/c1-15-10(13)7-12-11(14)16-8-9-5-3-2-4-6-9/h2-6H,7-8H2,1H3,(H,12,14) |
Methyl ([(benzyloxy)carbonyl]amino)acetate - Physico-chemical Properties
| Molecular Formula | C11H13NO4 |
| Molar Mass | 223.23 |
| Density | 1.19 |
| Melting Point | 22-26℃ |
| Boling Point | 147-151℃ |
| Flash Point | 174°C |
| Vapor Presure | 1.73E-05mmHg at 25°C |
| pKa | 10.85±0.46(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.5120 to 1.5160 |
Methyl ([(benzyloxy)carbonyl]amino)acetate - Introduction
CBZ-glycine methyl ester, also known as glycinate hydroxyformate (H-Gly-OH-OMe), is an organic compound. The following is a description of the properties, uses, preparation and safety information of CBZ-glycine methyl ester:
Nature:
CBZ-Glycine methyl ester is a colorless to slightly yellow solid, soluble in organic solvents such as ethanol, dimethylformamide and dichloromethane, and insoluble in water. It has a malonamide group protecting the hydroxyl group.
Use:
CBZ-glycine methyl ester is commonly used as a protecting group in organic synthesis. This is because it can protect hydrogen bonds in amino acids or other hydroxyl compounds, preventing unwanted reactions under certain specific reaction conditions. CBZ-glycine methyl ester can also be used to synthesize amino acids in peptides or drugs.
Preparation Method:
The preparation of CBZ-glycine methyl ester is usually carried out by the following steps:
1. reacting glycine with formyl chloride to generate glycine methyl ester;
2. Using urea and triethylamine as catalysts, glycine methyl ester reacts with chloroformic acid to generate CBZ-glycine methyl ester.
Safety Information:
Note the following safety information when using CBZ-glycine methyl ester:
1. CBZ-glycine methyl ester may cause irritation to skin, eyes and respiratory tract. Appropriate personal protective equipment such as gloves, safety glasses and protective face masks should be worn during operation.
2. Avoid inhalation or exposure to dust, fumes or vapors of CBZ-glycine methyl ester. Use in well-ventilated areas and avoid use in inappropriate environments.
3. if accidentally into the eyes or skin, should immediately rinse with plenty of water, and seek medical help.
4. when storing CBZ-glycine methyl ester, it should be kept in a dry, cool and ventilated place, away from fire and oxidant.
Nature:
CBZ-Glycine methyl ester is a colorless to slightly yellow solid, soluble in organic solvents such as ethanol, dimethylformamide and dichloromethane, and insoluble in water. It has a malonamide group protecting the hydroxyl group.
Use:
CBZ-glycine methyl ester is commonly used as a protecting group in organic synthesis. This is because it can protect hydrogen bonds in amino acids or other hydroxyl compounds, preventing unwanted reactions under certain specific reaction conditions. CBZ-glycine methyl ester can also be used to synthesize amino acids in peptides or drugs.
Preparation Method:
The preparation of CBZ-glycine methyl ester is usually carried out by the following steps:
1. reacting glycine with formyl chloride to generate glycine methyl ester;
2. Using urea and triethylamine as catalysts, glycine methyl ester reacts with chloroformic acid to generate CBZ-glycine methyl ester.
Safety Information:
Note the following safety information when using CBZ-glycine methyl ester:
1. CBZ-glycine methyl ester may cause irritation to skin, eyes and respiratory tract. Appropriate personal protective equipment such as gloves, safety glasses and protective face masks should be worn during operation.
2. Avoid inhalation or exposure to dust, fumes or vapors of CBZ-glycine methyl ester. Use in well-ventilated areas and avoid use in inappropriate environments.
3. if accidentally into the eyes or skin, should immediately rinse with plenty of water, and seek medical help.
4. when storing CBZ-glycine methyl ester, it should be kept in a dry, cool and ventilated place, away from fire and oxidant.
Last Update：2024-04-09 15:17:51
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